An internal ligand-bound, metastable state of a leukocyte integrin,
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An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2
How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin αXβ2. The αXβ2 ectodomain is bent; however, a lattice contact stabilizes its ligand-binding αI domain in a high affinity, open conformation. Much of the αI α7 helix unwinds, loses contact with the αI domain, and reshapes to form an ...
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تاریخ انتشار 2013